Cameron Redpath will miss the game versus Wales on Saturday due to injury.
Along with Redpath, flanker Jamie Ritchie and winger Sean Maitland drop out, also due to injury.
Blade Thompson, James Lang and Darcy Graham come into the starting 15 for the second round of the Six Nations.
Scotland lose experience with the replacements. Maitland and Richie have a combined 73 caps between them while the three to come in, Thompson, Lang and Graham have a combined 27 caps.
However experience doesn’t seem to be the benchmark of performance after Cameron Redpath’s showing versus England.
Redpath made an explosive start to his Scotland career debuting in the Calcutta Cup victory last Saturday.
The win at Twickenham was the first time in 38 years Scotland had won on English soil.
Scarlets back-row Blade Thomson will get his 9th cap against the Welsh while Harlequins centre James Lang gets his 5th cap and Edinburgh winger Darcy Graham his 13th cap.
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Apart from those three changes the team is the same one that defeated England 11-6.
Stuart Hogg will captain the side, Finn Russell remains at fly-half dictating Scotland’s attack and Duhan van der Merwe makes his sixth start for Scotland
South African born Van der Merwe is proving pretty prolific in a blue jersey having scored four tries in five tests including the only try of the game against England.

Gregor Townsend said before the game the performance at Twickenham was the benchmark Scotland need to aim towards for the rest of the series.
Even though Scotland lose a chunk of experience Townsend is confident in the players he is bringing in for Saturday’s test.
Townsend said of the game against the Welsh: “We are able to bring in three quality players in Blade, James and Darcy. They have been training well and are highly motivated to make the most of this opportunity.
“The squad performed to a level (against England) which has to be the benchmark throughout the tournament. Wales are also coming into this game after a win and will have the same objective, so it will be a tough challenge as always.”

Scotland v Wales, Murrayfield, Saturday 13 February, KO 16:45.